Combined Aerobic and Strength Training Improves Dynamic Stability and can Prevent against Static Stability Decline in Postmenopausal Women: A Randomized Clinical Trial.

OBJECTIVE: To analyze the effect of combined training (CT) in postural control and gait parameters in postmenopausal women. METHODS: A parallel-group, randomized, control study was conducted with 16 weeks of combined training (n = 16) versus a non-training control group (n = 12) in postmenopausal women (aged 59.3 ± 8.0). Pre and postintervention assessments included postural control (using an AMTI force platform - Advanced Mechanical Technology, Inc., Watertown, MA, USA) and gait impairments (using baropodometry). In addition, the upper limb strength and abdominal tests, as well as aerobic capacity, assessed functional indicators. RESULTS: The CT intervention in postmenopausal women resulted in improved gait (stride length (p = 0.006); speed (p = 0.013); double support time (p = 0.045); and improved postural control (displacement area of postural sway in a normal base of support with eyes open (p = 0.006). Combined training increased functional indicators (abdominal - p = 0.031; aerobic capacity - p = 0.002). CONCLUSION: In conclusion, combined aerobic plus strength training effectively improved gait and balance control in older women. The postmenopausal women from the CT group walked faster and with bigger steps after the intervention than the control group. In addition, they presented decreased postural sway in standing and decreased the percentage of double support time while walking, which means improved static and dynamic balance control and functional indicators.

OBJETIVO: Analisar o efeito do treinamento combinado (TC) no controle postural e nos parâmetros da marcha em mulheres na pós-menopausa. MéTODOS: Foi realizado um estudo controlado randomizado de grupos paralelos com 16 semanas de treinamento combinado (n = 16) versus um grupo controle sem treinamento (n = 12) em mulheres na pós-menopausa (59,3 ± 8,0 anos). As avaliações pré e pós-intervenção incluíram controle postural (usando a plataforma de força AMTI) e deficiências da marcha (usando baropodometria). Além disso, os testes de força de membros superiors e abdominal, bem como a capacidade aeróbica, avaliaram indicadores funcionais. RESULTADOS: A intervenção do TC em mulheres na pós-menopausa resultou em melhora da marcha (comprimento da passada (p = 0,006), velocidade (p = 0,013), tempo de apoio duplo (p = 0,045) e controle postural aprimorado (área de deslocamento da oscilação postural em base de apoio normal com olhos abertos (p = 0,006). O TC aumentou os indicadores funcionais (abdominal - p = 0,031; capacidade aeróbia - p = 0,002). CONCLUSãO: Em conclusão, o TC de força e aeróbico melhorou efetivamente o controle da marcha e do equilíbrio em mulheres idosas. As mulheres na pós-menopausa do grupo CT caminharam mais rápido e com passos maiores após a intervenção do que o grupo controle. Além disso, elas apresentaram redução da oscilação postural em pé e do percentual de tempo de apoio duplo durante a caminhada, o que significa melhora no controle do equilíbrio estático e dinâmico e dos indicadores funcionais.

Combined Aerobic and Strength Training Improves Dynamic Stability and can Prevent against Static Stability Decline in Postmenopausal Women: A Randomized Clinical Trial / O treinamento de força e aeróbio combinado melhora a estabilidade dinâmica e pode prevenir contra o declínio da estabilidade estática em mulheres na pósmenopausa: um ensaio clínico randomizado

Abstract Objective To analyze the effect of combined training (CT) in postural control and gait parameters in postmenopausal women. Methods A parallel-group, randomized, control study was conducted with 16 weeks of combined training (n = 16) versus a non-training control group (n = 12) in postmenopausal women (aged 59.3 ± 8.0). Pre and postintervention assessments included postural control (using an AMTI force platform - Advanced Mechanical Technology, Inc., Watertown, MA, USA) and gait impairments (using baropodometry). In addition, the upper limb strength and abdominal tests, as well as aerobic capacity, assessed functional indicators. Results The CT intervention in postmenopausal women resulted in improved gait (stride length (p = 0.006); speed (p = 0.013); double support time (p = 0.045); and improved postural control (displacement area of postural sway in a normal base of support with eyes open (p = 0.006). Combined training increased functional indicators (abdominal - p = 0.031; aerobic capacity - p = 0.002). Conclusion In conclusion, combined aerobic plus strength training effectively improved gait and balance control in older women. The postmenopausal women from the CT group walked faster and with bigger steps after the intervention than the control group. In addition, they presented decreased postural sway in standing and decreased the percentage of double support time while walking, which means improved static and dynamic balance control and functional indicators.

Resumo Objetivo Analisar o efeito do treinamento combinado (TC) no controle postural e nos parâmetros da marcha em mulheres na pós-menopausa. Métodos Foi realizado um estudo controlado randomizado de grupos paralelos com 16 semanas de treinamento combinado (n = 16) versus um grupo controle sem treinamento (n = 12) em mulheres na pós-menopausa (59,3 ± 8,0 anos). As avaliações pré e pós-intervenção incluíram controle postural (usando a plataforma de força AMTI) e deficiências da marcha (usando baropodometria). Além disso, os testes de força de membros superiors e abdominal, bem como a capacidade aeróbica, avaliaram indicadores funcionais. Resultados A intervenção do TC em mulheres na pós-menopausa resultou em melhora da marcha (comprimento da passada (p = 0,006), velocidade (p = 0,013), tempo de apoio duplo (p = 0,045) e controle postural aprimorado (área de deslocamento da oscilação postural em base de apoio normal com olhos abertos (p = 0,006). O TC aumentou os indicadores funcionais (abdominal - p = 0,031; capacidade aeróbia - p = 0,002). Conclusão Em conclusão, o TC de força e aeróbico melhorou efetivamente o controle da marcha e do equilíbrio em mulheres idosas. As mulheres na pós-menopausa do grupo CT caminharam mais rápido e com passos maiores após a intervenção do que o grupo controle. Além disso, elas apresentaram redução da oscilação postural em pé e do percentual de tempo de apoio duplo durante a caminhada, o que significa melhora no controle do equilíbrio estático e dinâmico e dos indicadores funcionais.

Aerobic training improves NAFLD markers and insulin resistance through AMPK-PPAR-α signaling in obese mice.

Liver steatosis is one of the main drivers for the development of whole-body insulin resistance. Conversely, aerobic training (AT) has been suggested as non-pharmacological tool to improve liver steatosis, however, the underlying molecular mechanism remains unclear. Therefore, the aim of this study was to analyze the effect of 8-weeks AT in non-alcoholic liver disease (NAFLD) outcomes in obese mice. Male C57BL/6 J wild type (WT) were fed with standard (SD) or high-fat diet (HFD) for 12-weeks. Another group fed with HFD underwent 8-weeks of AT (60% of maximum velocity), initiated at the 5th week of experimental protocol. We measured metabolic, body composition parameters, protein and gene expression inflammatory and metabolic mediators. We found that AT attenuates the weight gain, but not body fat accumulation. AT improved triacylglycerol and non-esterified fatty acid plasma concentrations, and also whole-body insulin resistance. Regarding NAFLD, AT decreased the progression of macrovesicular steatosis and inflammation through the upregulation of AMPK Thr172 phosphorylation and PPAR-α protein expression. Moreover, although no effects of intervention in PPAR-γ protein concentration were observed, we found increased levels of its target genes Cd36 and Scd1 in exercised group, demonstrating augmented transcriptional activity. AT reduced liver cytokines concentrations, such as TNF-α, IL-10, MCP-1 and IL-6, regardless of increased Ser536 NF-κB phosphorylation. In fact, none of the interventions regulated NF-κB target genes Il1b and Cccl2, demonstrating its low transcriptional activity. Therefore, we conclude that AT attenuates the progression of liver macrovesicular steatosis and inflammation through AMPK-PPAR-α signaling and PPAR-γ activation, respectively, improving insulin resistance in obese mice.

Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy.

The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed to evaluate the effects of endurance exercise on time-dependent muscle atrophy caused by doxorubicin. For this, C57 BL/6 mice were subcutaneously inoculated with Lewis lung carcinoma cells (LLC group). One week after the tumor establishment, a group of these animals initiated the doxorubicin chemotherapy alone (LLC + DOX group) or combined with endurance exercise (LLC + DOX + EXER group). One group of animals was euthanized after the chemotherapy cycle, whereas the remaining animals were euthanized one week after the last administration of doxorubicin. The practice of exercise combined with chemotherapy showed beneficial effects such as a decrease in tumor growth rate after chemotherapy interruption and amelioration of premature death due to doxorubicin toxicity. Moreover, the protein degradation levels in mice undergoing exercise returned to basal levels after chemotherapy; in contrast, the mice treated with doxorubicin alone experienced an increase in the mRNA expression levels of the proteolytic pathways in gastrocnemius muscle (Trim63, Fbxo32, Myostatin, FoxO). Collectively, our results suggest that endurance exercise could be utilized during and after chemotherapy for mitigating muscle atrophy promoted by doxorubicin and avoid the resumption of tumor growth.

Practice of physical activity and dysmobility syndrome in community-dwelling older adults.

The aim this study was to analyze the association between insufficient physical activity and dysmobility syndrome (DS) in community-dwelling older adults. In total, 375 subjects were evaluated aged ≥60 years. For the diagnosis of DS the presence of ≥3 clinical factors was considered: (a) low muscle mass; (b) low muscular strength; (c) low gait speed; (d) high body fat, and (e) osteoporosis. Information relating to the practice of habitual physical activity (HPA) was obtained using a questionnaire and accelerometry. The chi-square test was used to verify the association between HPA and DS and analysis of binary logistic regression to build multiple models. Insufficiently active older adults are approximately 2 times (95% confidence interval, 1.14-3.79) more likely to have DS, independent of body mass index, smoking and ethnicity. The insufficient practice of physical activity is associated with DS in older adults, mainly in women and older.

Regulation of autophagy as a therapy for immunosenescence-driven cancer and neurodegenerative diseases: The role of exercise.

Aging is one of the risk factors for the development of low-grade inflammation morbidities, such as several types of cancer and neurodegenerative diseases, due to changes in the metabolism, hormonal secretion, and immunosenescence. The senescence of the immune system leads to improper control of infections and tissue damage increasing age-related diseases. One of the mechanisms that maintain cellular homeostasis is autophagy, a cell-survival mechanism, and it has been proposed as one of the most powerful antiaging therapies. Regular exercise can reestablish autophagy, probably through AMP-activated protein kinase activation, and help in reducing the age-related senescence diseases. Therefore, in this study, we discuss the effects of exercise training in immunosenescence and autophagy, preventing the two main age-related disease, cancer and neurodegeneration.

Cardiovascular effects of 16 weeks of martial arts training in adolescents / Efeitos cardiovasculares de 16 semanas de treinamento de artes marciais em adolescentes / Efectos cardiovasculares de 16 semanas de entrenamiento de artes marciales en adolescentes

ABSTRACT Introduction: Sedentary habits increase the chances of developing cardiovascular disease. Physical activity is one of the means of prevention and treatment of these diseases, thus martial arts represent a dynamic option in promoting physical activity. Objective: The objective of the study is analyze the effects of 16 weeks of Martial Arts (Muay Thai or judo) training on cardiovascular variables in adolescents. Methods: The sample consisted of 40 adolescents, aged 11 to 14 years, divided into two groups: Martial Arts (n=28) and control (n=12). Weight and height measurements were taken to calculate body mass index. Systolic and diastolic blood pressure (BP), heart rate (HR) at rest, pulse pressure (PP) and rate-pressure product (RPP), were also measured. The intervention was carried out through Martial Arts (Muay Thai and judo) training held twice a week for 90 minutes, over 16 weeks. The control group did not undergo any training. The statistical analysis was performed using the following tests: Shapiro-Wilks, Levene's, analysis of covariance (ANCOVA), eta-squared effect size and the net-effect, using SPSS 15.0 software and a significance level of 5%. Results: There was no statistical difference between the control and Martial Arts groups for the sample characterization. There was a significant difference in systolic BP in the Martial Arts group when compared with the control group (p-value=0.049). The effect size can be considered moderate (effect size=0.163), with a good net-effect (3.4 mmHg). Conclusion: This study showed that 16 weeks of Martial Arts decreased systolic BP in normotensive adolescents. Level of Evidence II; Therapeutic studies - Investigating the results of treatment.

RESUMO Introdução: Os hábitos sedentários aumentam as chances de desenvolvimento de doenças cardiovasculares. A atividade física é um dos meios de prevenção e tratamento dessas doenças, sendo assim, as artes marciais aparecem como uma opção de caráter dinâmico no incentivo à prática de atividades físicas. Objetivos: O objetivo do estudo consiste em analisar os efeitos de 16 semanas de treinamento de artes marciais (Muay Thai ou Judô) sobre as variáveis cardiovasculares nos adolescentes. Métodos: A amostra foi constituída por 40 adolescentes de 11 a 14 anos, divididos em dois grupos: artes marciais (n=28) e controle (n=12). As medições de peso e altura foram realizadas para o cálculo do índice de massa corporal. Foram medidas também a pressão arterial sistólica e diastólica (PA), a frequência cardíaca (FC) em repouso, a pressão de pulso (PP) e o duplo produto (DP). A intervenção foi realizada através da prática de artes marciais (Muay Thai e Judô), realizada duas vezes por semana, durante 90 minutos, por 16 semanas. O grupo controle não realizou nenhum tipo de treinamento. A análise estatística foi feita utilizando os seguintes testes: Shapiro-Wilks, Levene, análise de covariância (ANCOVA), tamanho do efeito eta-squared e efeito líquido, utilizando o software SPSS 15.0 e nível de significância de 5%. Resultados: Não houve diferença estatística entre o grupo controle e o grupo de artes marciais para a caracterização da amostra. Houve diferença significativa na PA sistólica no grupo de artes marciais quando comparado com o grupo controle (valor p=0,049). A dimensão do efeito pode ser considerada moderada (dimensão do efeito=0,163), com um bom efeito líquido (3,4 mmHg). Conclusão: Este estudo demonstrou que 16 semanas de artes marciais diminuíram a PA sistólica em adolescentes normotensos. Nível de Evidência II; Estudos terapêuticos - Investigação dos resultados do tratamento.

RESUMEN Introducción: Los hábitos sedentarios aumentan las posibilidades de desarrollo de enfermedades cardiovasculares. La actividad física es uno de los medios de prevención y tratamiento de esas enfermedades, siendo así, las artes marciales aparecen como una opción de carácter dinámico en el incentivo a la práctica de actividades físicas. Objetivos: El objetivo del estudio es analizar los efectos de 16 semanas de entrenamiento de artes marciales (Muay Thai o Judo) sobre las variables cardiovasculares en adolescentes. Métodos: La muestra fue constituida de 40 adolescentes de 11 a 14 años, divididos en dos grupos: artes marciales (n=28) y control (n=12). Fueron realizadas mediciones de peso y altura para calcular el índice de masa corporal. Fueron medidas también la presión arterial sistólica y diastólica (PA), frecuencia cardíaca (FC) en reposo, la presión de pulso (PP) y el doble producto (DB). La intervención fue realizada a través de la práctica de artes marciales (Judo y Muay Thai), realizada dos veces por semana durante 90 minutos, por 16 semanas. El grupo control no realizó ningún tipo de entrenamiento. El análisis estadístico fue hecho usando los siguientes tests; Shapiro-Wilk, Levene, análisis de covarianza (ANCOVA), tamaño de efecto eta-squared y efecto neto, usando el software SPSS 15.0 y el nivel de significación de 5%. Resultados: No hubo diferencia estadística significativa entre el grupo control y el grupo de artes marciales para la caracterización de la muestra. Hubo diferencia significativa en la PA sistólica en el grupo de artes marciales, cuando comparado con el grupo control ( valor p=0,049). La dimensión del efecto puede ser considerada moderada (dimensión del efecto=0,163) con un buen efecto neto (3,4 mmHg). Conclusión: Este estudio demostró que 16 semanas de artes marciales disminuyeron la PA sistólica en adolescentes normotensos. Nivel de Evidencia II; Estudios terapéuticos - Investigación de los resultados del tratamiento.

Relationship between total and segmental bone mineral density and different domains of physical activity among children and adolescents: cross-sectional study

ABSTRACT BACKGROUND: This study aimed to investigate the relationship between total and segmental bone mineral density (BDM) and physical activity (PA) in different domains (school, leisure and sports) among adolescents and children. DESIGN AND SETTING: Cross-sectional study in the Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP). METHODS: The study sample consisted of 173 children and adolescents (10.31 ± 1.87 years). The BMDs for the whole body (WB) and the regions of the trunk and legs were measured using dual energy X-ray absorptiometry (DXA). PA was measured using the Baecke questionnaire. A regression model was used to analyze the relationship between all the BMDs and the different domains of PA. RESULTS: 41.5% of the adolescents had high percentages of body fat. Regarding the comparison between physically active and insufficiently active adolescents, there were no statistically significant differences in any BMD variables (P > 0.05). The BMD of the legs showed positive relationships with the total PA (β = 0.009; P = 0.013) and sports PA (β = 0.010; P = 0.049) after insertion of the confounders. Similarly, the WB BMD showed the same relationships (total PA: β = 0.005; P = 0.045; and sports PA: β = 0.008; P = 0.049). No relationship was found between leisure and school PA and any of the BMDs (P > 0.05). CONCLUSION: The results indicated that practice of sport was related to higher BMD values, independent of sex, age and body fatness.

Relationship between total and segmental bone mineral density and different domains of physical activity among children and adolescents: cross-sectional study.

BACKGROUND: This study aimed to investigate the relationship between total and segmental bone mineral density (BDM) and physical activity (PA) in different domains (school, leisure and sports) among adolescents and children. DESIGN AND SETTING: Cross-sectional study in the Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP). METHODS: The study sample consisted of 173 children and adolescents (10.31 ± 1.87 years). The BMDs for the whole body (WB) and the regions of the trunk and legs were measured using dual energy X-ray absorptiometry (DXA). PA was measured using the Baecke questionnaire. A regression model was used to analyze the relationship between all the BMDs and the different domains of PA. RESULTS: 41.5% of the adolescents had high percentages of body fat. Regarding the comparison between physically active and insufficiently active adolescents, there were no statistically significant differences in any BMD variables (P > 0.05). The BMD of the legs showed positive relationships with the total PA (ß = 0.009; P = 0.013) and sports PA (ß = 0.010; P = 0.049) after insertion of the confounders. Similarly, the WB BMD showed the same relationships (total PA: ß = 0.005; P = 0.045; and sports PA: ß = 0.008; P = 0.049). No relationship was found between leisure and school PA and any of the BMDs (P > 0.05). CONCLUSION: The results indicated that practice of sport was related to higher BMD values, independent of sex, age and body fatness.

Exercício físico como tratamento não farmacológico para a melhora da saúde pós-menopausa / Physical exercise as non-pharmacological treatment for the improvement of postmenopause health / Ejercicio físico como tratamiento no farmacológico para la mejora de la salud posmenopausia

RESUMO O período da pós-menopausa é caracterizado por 12 meses consecutivos de amenorreia. Além de afetar o sistema reprodutivo e a produção de hormônios sexuais, principalmente o estrógeno, essas mulheres apresentam aumento da gordura corporal total, principalmente na região central, o que está relacionado com o desenvolvimento de diversas doenças crônicas, como dislipidemia, aterosclerose e resistência à insulina. Dessa forma, diferentes programas de exercício físico, aeróbico, resistido ou combinado (aeróbico e resistido em uma mesma sessão) podem ser uma forma interessante de tratamento não farmacológico para a prevenção e melhora dos desfechos. Entretanto, as adaptações promovidas pelos diferentes programas de exercício sobre a composição corporal, perfil lipídico e glicêmico não estão claras na literatura e precisam ser elucidadas. Assim sendo, esta revisão tem como objetivo discutir as diferentes adaptações do treinamento aeróbico, resistido e combinado na composição corporal, perfil lipídico e glicêmico de mulheres na pós-menopausa.

ABSTRACT The postmenopausal period is characterized by 12 consecutive months of amenorrhea. In addition to affecting the reproductive system and the production of sex hormones, mainly estrogen, these women present an increase in total body fat especially in the central region, which is related to the development of several chronic diseases such as dyslipidemia, atherosclerosis, and insulin resistance. Therefore, different programs of physical exercise, aerobic or resistance or combined (aerobic and resistance in the same session) may be an interesting form of non-pharmacological treatment for the prevention and improvement of outcomes. However, the adaptations promoted by the different exercise programs on the body composition, lipid and glycemic profiles are not clear in the literature and need to be elucidated. Hence, this review aims to discuss the different adaptations of aerobic, resistance and combined training in body composition, lipid, and glycemic profile of postmenopausal women.

RESUMEN El período de posmenopáusico se caracteriza por 12 meses consecutivos de amenorrea. Además de afectar el sistema reproductivo y la producción de hormonas sexuales, principalmente el estrógeno, estas mujeres tienen aumento de grasa corporal total, particularmente en la región central, lo que está relacionado con el desarrollo de diversas enfermedades crónicas, como dislipidemia, aterosclerosis y resistencia a la insulina. Por lo tanto, diferentes programas de ejercicio físico, aeróbico, de resistencia o combinado (aeróbico y de resistencia en una misma sesión) pueden ser una manera interesante de tratamiento no farmacológico para la prevención y mejora de los resultados. Sin embargo, las adaptaciones promovidas por los diferentes programas de ejercicios sobre la composición corporal, perfil de lípidos y glucémico no están claras en la literatura y necesitan ser elucidadas. De esta manera, esta revisión tiene como objetivo discutir las diferentes adaptaciones de entrenamiento aeróbico, de resistencia y combinado en la composición corporal, perfil lipídico y glucémico de mujeres en la posmenopausia.

The effect of different training modalities on physical fitness in women over 50 years of age

Abstract It is not yet clear which physical exercise protocols have greater potential to mitigate the functional decline in physical fitness (coordination, flexibility, strength, agility and cardiorespiratory capacity). Thus, the objective of this study was to compare different training modalities on physical fitness in women over 50 years of age and understand which training protocol is more effective for promoting significant improvements in physical fitness. The initial sample consisted of 79 subjects, of which 17 dropped out, resulting in a total of 62 subjects who completed the study and are included in the analysis (n = 62). The average age of the study population was 60.1±5.4 years, divided into five groups: aerobic training, concurrent training, multimodal training, functional training and control group. Physical fitness was analyzed through AAHPERD (American Alliance for Health, Physical Education, Recreation and Dance) tests (0 and eighth weeks). The ANOVA analyses (aleatory effect) show a main effect of time for coordination (p<0.001), strength (p = 0.004), agility (p<0.001) and cardiorespiratory capacity (p<0.001), and statistically significant interactions for coordination (p = 0.003) and cardiorespiratory capacity (p = 0.033). When comparing the average relative differences between the group (Δ%), significant improvement was observed in coordination and agility (p<0.001) in the multimodal and functional training groups. For cardiorespiratory fitness, there was a significant improvement in the aerobic, concurrent and multimodal training groups (p<0.001) and strength increased in the functional training group (p = 0.04). Functional training was demonstrated to be more effective at promoting significant improvements in physical fitness than the other investigated exercise protocols.

Postprandial lipoprotein profile in two modes of high-intensity intermittent exercise.

The aim of present study was to compare blood lipid postprandial profile response in two modes of high-intensity intermittent exercise. Twelve individuals (6 men and 6 women) were submitted to a maximal incremental test (to determine maximal aerobic power [MAP] and V. O2peak [peak oxygen uptake]), high-intensity intermittent all-out exercise (60×8-sec bouts interspersed by 12-sec passive recovery) and fixed high-intensity intermittent exercise (100% maximal aerobic speed, consisted of 1-min repetitions at MAP [70 rpm] separated by 1-min of passive recovery). Blood samples were collected pre, immediately, 45 and 90-min postexercise. Serum was analyzed for total cholesterol and its ratio, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), very low-density lipoprotein (VLDL) cholesterol, and triacylglycerol (TAG). For TAG there was a main effect of moment with higher values immediately postexercise compared to 45-min postexercise. For VLDL there was a main effect to moment with higher values immediately post exercise than pre and 45-min postexercise; higher values 90-min postexercise than 45-min postexercise. There was no effect for HDL-c, LDL-c, and cholesterol. For area under the curve there was no difference for any variable. Our results indicated that both kinds of acute exercise session lead to no improvement in the acute response of serum lipid profile of healthy young.

Inflammatory Mechanisms Associated with Skeletal Muscle Sequelae after Stroke: Role of Physical Exercise.

Inflammatory markers are increased systematically and locally (e.g., skeletal muscle) in stroke patients. Besides being associated with cardiovascular risk factors, proinflammatory cytokines seem to play a key role in muscle atrophy by regulating the pathways involved in this condition. As such, they may cause severe decrease in muscle strength and power, as well as impairment in cardiorespiratory fitness. On the other hand, physical exercise (PE) has been widely suggested as a powerful tool for treating stroke patients, since PE is able to regenerate, even if partially, physical and cognitive functions. However, the mechanisms underlying the beneficial effects of physical exercise in poststroke patients remain poorly understood. Thus, in this study we analyze the candidate mechanisms associated with muscle atrophy in stroke patients, as well as the modulatory effect of inflammation in this condition. Later, we suggest the two strongest anti-inflammatory candidate mechanisms, myokines and the cholinergic anti-inflammatory pathway, which may be activated by physical exercise and may contribute to a decrease in proinflammatory markers of poststroke patients.

Comparison between two models of training with regard to resting energy expenditure and body composition in obese adolescents / Comparação entre dois modelos de treinamento sobre o gasto energético de repouso e a composição corporal de adolescentes com obesidade

Abstract Different types of physical activity programs have been used with the purpose of improving body composition and increasing resting energy expenditure (REE) in obese adolescents. The aim of the present study was to compare the effects of two training models on REE and body composition in this population. The study included 20 obese male adolescents, who were randomly assigned to follow two training models: strength training (n=8, age=13,4±1.0) and functional training (n=12, age= 13.0±1.1). Body composition variables were estimated by dual-energy X-ray absorptiometry. REE was assessed by indirect calorimetry using the QUARK-PFT equipment (COSMED, Rome, Italy). The training protocol consisted of 30 minutes of aerobic training followed by 30 minutes of strength training (ST) or functional training (FT), both with a duration of 20 weeks. There were no significant differences between the two training models with regard to body composition (fat mass, FT= -7.6±5.5% vs. ST= -8.9±6.2%; p=0.620), (lean body mass, FT= 9.0±5.3% vs. ST= 6.8±6.7%; p=0.431) and to REE (FT= 19.6±15.3% vs. ST= 10.7±24.5%; p=0.331). Moreover, lean body mass (p=0.01) and fat mass (0.01) had an influence on REE. No differences were observed between the two training models, but both were effective in improving body composition and increasing REE in obese adolescents. Furthermore, the present study showed the importance of systematic physical training, since lean body mass and fat mass contributed to the increase in REE after the training period.

Resumo Diferentes tipos de programas de exercícios físicos têm sido utilizados na tentativa de melhorar a composição corporal e aumentar o gasto energético de repouso (GER) de adolescentes obesos. O objetivo foi comparar os efeitos de dois modelos de treinamento sobre o gasto energético de repouso e a composição corporal de adolescentes com obesidade. Participaram do estudo vinte adolescentes obesos do sexo masculino, foram divididos de forma aleatória em dois modelos de treinamento: treinamento contra resistência (n=8, idade=13,4±1,0) e treinamento funcional (n=12, idade= 13,0±1,1). As variáveis de composição corporal foram estimadas pela densitometria radiológica de dupla energia. O GER foi realizado por meio da calorimetria indireta usando o equipamento QUARK-PFT (COSMED, Roma, Itália). O protocolo de treinamento consistiu de 30 minutos de treino aeróbio seguidos de 30 minutos de treino contra resistência (TC) ou funcional (TF), ambos durante 20 semanas. Não houve diferenças significantes entre os dois modelos de treinamento na composição corporal (massa gorda, TF= -7,6±5,5% x TC= -8,9±6,2%; p=0,620), (massa corporal magra, TF= 9,0±5,3% x TC= 6,8±6,7%; p=0,431) e no GER (TF= 19,6±15,3% x TC= 10,7±24,5%; p=0,331). Além disso, a massa corporal magra (p=0,01) e massa gorda (p=0,01) influenciam o GER. Não há diferença entre os dois modelos de treinamento, porém ambos são eficazes na redução da composição corporal e aumento do GER de adolescentes obesos. Adicionalmente, foi verificada a importância do treinamento físico sistematizado, uma vez que a massa corporal magra e massa gorda contribuíram para o aumento do GER após o treinamento.

Normative values of functional fitness in non-active postmenopausal women / Valores normativos de aptidão funcional em mulheres não ativas na pós-menopausa

Abstract The aim of this study was to propose the normative table for the non-active postmenopausal Brazilian population composed of women aged 50-69 years through the AAHPERD functional fitness test battery. This is a cross-sectional study with 170 postmenopausal women (FSH dose> 26.72 mIU / L). The population was divided into two groups: 50-59 years (n = 97) and 60-69 years (n = 73). The inclusion criteria were not having participated of systematic motor intervention in the six months prior to the study period; not presenting motor or cognitive impairments that could impair the performance of evaluation protocols and absence of comorbidities that could prevent or limit evaluations. The group aged 50-59 years showed mean values of 55.6 ± 2.9 years for age, 54.0 ± 21.1 mIU / ml for FSH, 11.3 ± 1.8 seconds for coordination 20.2 ± 4.0 repetitions for strength, 51.9 ± 11.8 cm for flexibility, 23.0 ± 2.4 seconds for speed and 497 ± 39 seconds for aerobic resistance. The group aged 60-69 years showed mean values of 64.2 ± 2.8 years of age, 54.9 ± 16.1 mIU / ml for FSH, 11.5 ± 2.5 seconds for coordination, 20.2 ± 4.3 repetitions for strength, 54.4 ± 10.9 cm for flexibility, 24.5 ± 4.0 seconds for speed and 507 ± 47 seconds for aerobic resistance. The proposal of a normative table was made possible with the data analyzed, which is a new reference regarding functional fitness studies especially in physically inactive postmenopausal women.

Resumo Objetivou-se propor a tabela normativa para a população brasileira de mulheres não ativas na pós-menopausa entre 50 e 69 anos por meio da bateria de teste de aptidão funcional da AAHPERD. Estudo de característica transversal, com 170 mulheres na pós-menopausa (dosagem de FSH>26,72 mIU/L). A população foi dividida em dois grupos: 50 a 59 anos (n=97) e de 60 a 69 anos (n=73). Os critérios de inclusão foram não participar de intervenção motora sistematizada nos seis meses anteriores ao período do estudo; não apresentar comprometimentos motores ou cognitivos que inviabilizassem a realização dos protocolos de avaliação, não apresentar comorbidade que pudessem impedir ou limitar a realização das avaliações. O grupo 50 a 59 anos apresentou valores médios de 55,6 ± 2,9 anos de idade, 54,0 ± 21,1 mUI/ ml para FSH, 11,3 ± 1,8 segundos para coordenação, 20,2 ± 4,0 repetições para força, 51,9 ± 11,8 centímetros para flexibilidade, 23,0 ± 2,4 segundos para agilidade e 497 ± 39 segundos para resistência aeróbia. O grupo de 60 a 69 anos apresentou média de 64,2 ± 2,8 anos de idade, 54,9 ± 16,1 mUI/ml para o FSH, 11,5 ± 2,5 segundos para coordenação, 20,2 ± 4,3 repetições para força, 54,4 ± 10,9 centímetros para flexibilidade, 24,5 ± 4,0 segundos para agilidade e 507 ± 47 segundos para resistência aeróbia. A proposta de apresentar uma tabela normativa foi possível com os dados analisados, sendo essa uma nova referência em relação a estudos de aptidão funcional especialmente em mulheres fisicamente inativas na pós-menopausa.

Moderate rest intervals are superior to short intervals for improving PAI-1 following exhaustive exercise in recreational weightlifters.

This study investigated the influence of short and moderate recovery intervals on lipid profiles and plasminogen activator inhibitor-1 (PAI-1) following exhaustive strength exercise in recreational weightlifters. Seven subjects performed two conditions in a randomized order: short, 90% of one maximum repetition (1RM) and 30-sec rest allowed between sets; moderate, 90% of 1RM and 90-sec rest allowed between sets. Total cholesterol (Chol), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triacylglycerol (TAG), Chol/HDL-c ratio and PAI-1 concentrations were assessed at baseline, immediately postexercise, and 15- and 30-min postexercise (post-15 and post-30). The LDL-c concentrations decreased and HDL-c concentrations increased in both conditions but without significant differences (LDL-c: 30 sec: pre, 82.0±19.5 mg/dL, immediately, 73.9±16.4 mg/dL, 90 sec: pre, 75.9±30.8 mg/dL, immediately, 66.2±35.5 mg/dL, P=0.423; HDL-c: 30 sec: pre, 53.5±9.2 mg/dL, immediately, 61.4±11.4 mg/dL; 90 sec: pre, 55.8±11.1 mg/dL, immediately, 84.9±27.8, mg/dL; P=0.146). On the other hand, PAI-1 had a tendency to decrease only in the 90-sec condition (pre, 7,754.9±2,927.7 pg/mL; immediately, 5,313.1±4,637.4 pg/mL; P=0.085). There was a positive correlation between PAI-1 and Chol (30 sec: r=0.83, 90 sec: r=0.91; P<0.05), PAI-1 and fat-free mass in both conditions (30 sec post-15: r=0.79, post-30: r=081, P<0.05; 90 sec immediately: r=0.77, post-15: r=0.81; P<0.05), and PAI-1 and TAG only in 30 sec (r=0.87, P<0.05). Short and moderate intervals of recovery improve lipid profiles after heavy strength exercise but only 90 sec induced greater improved in PAI-1 concentration in recreational weightlifters.

[Assessment of functional fitness through the set of AAHPERD tests in women after menopause: Is there a decline between the fifth and sixth decades of life?]. / Avaliação da aptidão funcional através do conjunto de testes da AAHPERD em mulheres na pós-menopausa: existe declínio entre a quinta e sexta década de vida?

PURPOSE: to analize the level of functional fitness of a group of postmenopausal women in the city of Presidente Prudente using the set of functional fitness tests of the American Alliance for Health, Physical Education, Recreation and Dance and to check whether there are differences between groups of women in the fifth and sixth decade of life. METHODS: This was a cross-sectional study conducted on 175 postmenopausal women (follicle stimulating hormone level>26.72 mIU/L) in the city of Presidente Prudente in 2013. The inclusion criteria were not being part of any type of systematic motor intervention for at least six months before the collection of research data; absence of motor or cognitive impairment that would prevent the evaluation protocols, and absence of chronic or degenerative disease, musculoskeletal injury or comorbidity that could prevent or limit the evaluations. The women were evaluated by the same trained examiners. The 50 to 59 year group showed a mean age of 55.3 ± 4.5 years, mean FSH values of 53.5 ± 21.1 mIU/mL, mean coordination of 11.4 ± 2.2 seconds, mean strength of 20.1 ± 3.9 repetitions, mean flexibility of 51.7 ± 11.8 cm, mean 23.2 ± 2.8 seconds agility and mean aerobic resistance of 500 ± 43/2. The 60 to 69 year group had a mean age of 65.1 ± 4.1 years with FSH 54.9 ± 15.9, 11.6 ± 2.6 seconds coordination, strength 20.3 ± 4.7 repetitions, 54.6 ± 11.2 cm flexibility, agility 24.7 ± 4.3 seconds, and aerobic resistance of 508 ± 51 seconds. CONCLUSION: It was possible to analyze the functional fitness of postmenopausal women through the set of the American Alliance testing for Health, Physical Education, Recreation and Dance with no significant differences between groups for the variables strength, flexibility, aerobic capacity and coordination, and with only the speed variable showing significant differences. We recommend further studies seeking to formulate normative values for the population in question.

Avaliação da aptidão funcional através do conjunto de testes da AAHPERD em mulheres na pós-menopausa: existe declínio entre a quinta e sexta década de vida? / Assessment of functional fitness through the set of AAHPERD tests in women after menopause: Is there a decline between the fifth and sixth decades of life?

OBJETIVO: analisar o nível de aptidão funcional de um grupo de mulheres na pós-menopausa da cidade de Presidente Prudente por meio do conjunto de testes de aptidão funcional da American Aliance for Health, Physical Education, Recreation and Dance e verificar se existe diferença entre grupos de mulheres na quinta e sexta década de vida. MÉTODOS: estudo de característica transversal, com 175 mulheres na pós-menopausa (dosagem de hormônio folículo estimulante>26,72 mIU/L) desenvolvido na cidade de Presidente Prudente no ano de 2013. Os critérios de inclusão foram não ter feito parte de nenhum tipo de intervenção motora sistematizada durante, pelo menos, seis meses do período que antecedeu a coleta de dados da investigação; não apresentar comprometimentos motores ou cognitivos que inviabilizassem a realização dos protocolos de avaliação, não apresentar doença crônica ou degenerativa, lesão musculo-esquelética ou comorbidade que pudessem impedir ou limitar a realização das avaliações. As avaliações foram conduzidas pelos mesmos avaliadores treinados. O grupo 50 a 59 anos apresentou valores médios para idade de 55,3±4,5 anos, FSH de 53,5±21,1 mUI/mL, coordenação 11,4±2,2 segundos, força 20,1±3,9 repetições, flexibilidade 51,7±11,8 centímetros, agilidade 23,2±2,8 segundos e Resistência aeróbia 500±43 segundos e o grupo 60 a 69 anos apresentou idade média de 65,1±4,1 anos com FSH de 54,9±15,9, coordenação 11,6±2,6 segundos, força 20,3±4,7 repetições, flexibilidade 54,6±11,2 centímetros, agilidade 24,7±4,3 segundos e Resistência aeróbia 508±51 segundos. CONCLUSÃO: foi possível analisar a aptidão funcional de mulheres na pós-menopausa por meio do conjunto de testes da American Aliance for Health, Physical Education, Recreation and Dance não havendo diferenças significativas para as variáveis força, flexibilidade, capacidade aeróbia e coordenação, sendo que apenas a variável agilidade demonstrou diferenças significativas. Recomenda-se outros ...

PURPOSE: to analize the level of functional fitness of a group of postmenopausal women in the city of Presidente Prudente using the set of functional fitness tests of the American Alliance for Health, Physical Education, Recreation and Dance and to check whether there are differences between groups of women in the fifth and sixth decade of life. METHODS: This was a cross-sectional study conducted on 175 postmenopausal women (follicle stimulating hormone level>26.72 mIU/L) in the city of Presidente Prudente in 2013. The inclusion criteria were not being part of any type of systematic motor intervention for at least six months before the collection of research data; absence of motor or cognitive impairment that would prevent the evaluation protocols, and absence of chronic or degenerative disease, musculoskeletal injury or comorbidity that could prevent or limit the evaluations. The women were evaluated by the same trained examiners. The 50 to 59 year group showed a mean age of 55.3±4.5 years, mean FSH values of 53.5±21.1 mIU/mL, mean coordination of 11.4±2.2 seconds, mean strength of 20.1±3.9 repetitions, mean flexibility of 51.7±11.8 cm, mean 23.2±2.8 seconds agility and mean aerobic resistance of 500±43/2 . The 60 to 69 year group had a mean age of 65.1±4.1 years with FSH 54.9±15.9, 11.6±2.6 seconds coordination, strength 20.3±4.7 repetitions, 54.6±11.2 cm flexibility, agility 24.7±4.3 seconds, and aerobic resistance of 508±51 seconds. CONCLUSION: It was possible to analyze the functional fitness of postmenopausal women through the set of the American Alliance testing for Health, Physical Education, Recreation and Dance with no significant differences between groups for the variables strength, flexibility, aerobic capacity and coordination, and with only the speed variable showing significant differences. We recommend further studies seeking to formulate normative values for the population in question. .

[Effect of a short-term functional training program on body composition in postmenopausal women]. / Efeito de um programa de treinamento funcional de curta duração sobre a composição corporal de mulheres na pós-menopausa.

PURPOSE: To evaluate the effect of 8 weeks of functional training on body composition in postmenopausal women. METHODS: The study was conducted on 38 postmenopausal women, divided into two groups: Training Group (TG) and Control Group (CG). TG women (n = 21) performed a program of physical exercise for a period of 8 weeks, 3 times a week on nonconsecutive days, with 90 minutes per session. For the same period, CG women (n = 17) did not perform any systematic physical activity. All participants were assessed at baseline and after 8 weeks. The evaluations were performed by the same trained raters. Analysis of body composition was performed using dual-energy X-ray absorptiometry (DEXA), which allows estimation of body composition in the whole body and by segment. TG participants performed a functional exercise program 3 days a week (non-consecutive), with 11 stations consisting of exercises developed in circuit format sessions. The objectives of the exercises were the development of strength, agility, coordination and proprioception, followed by aerobic exercise (walking). After normality of the data was determined by the Shapiro-Wilk test (p < 0.05), we applied the Student t-test for independent samples to check for possible differences in anthropometric variables and body composition between groups at both times of intervention (pre and post-test). All analyses were performed using the SPSS software v. 17.0 (SPSS Inc., Chicago, IL, USA) with the level of significance set at 5%. RESULTS: At baseline, no significant difference was observed between groups regarding anthropometric body variables or age composition, indicating homogeneity of the groups. After 8 weeks of training, significant differences were observed between TG and CG regarding fat - CG = 0.2 ± 0.7 and TG = -0.4 ± 0.5, total body fat (kg) - CG = 0.2 ± 1.3 and TG = -0.7 ± 0.8, and total weight - CG = 0.4 ± 1.4 and TG = -0.6 ± 1.1. Percent body fat was reduced in terms of absolute values, although without significance: CG = 0.1 ± 1.5 and TG = -0.8 ± 1.5. CONCLUSION: Functional training in circuit format can be used as a strategy to alter body composition in postmenopausal women, particularly in terms of reduction of adipose tissue. This is a model that promotes high adhesion on the part of the participants, suggesting that it is an attractive proposal for the investigated age group.

Efeito de um programa de treinamento funcional de curta duração sobre a composição corporal de mulheres na pós-menopausa / Effect of a short-term functional training program on body composition in postmenopausal women

OBJETIVO: Avaliar o efeito de 8 semanas de treinamento funcional sobre a composição corporal de mulheres na pós-menopausa. MÉTODOS: Participaram do estudo 38 mulheres menopausadas, distribuídas em dois grupos: Grupo Treino (GT) e Grupo Controle (GC). As participantes do GT (n=21) realizaram, por um período de 8 semanas, um programa de exercícios físicos, com frequência de 3 vezes por semana, em dias não consecutivos, e duração de 90 minutos por sessão. Pelo mesmo período, as mulheres do GC (n=17) não realizaram nenhum tipo de atividade física sistematizada. Todas as participantes foram avaliadas no momento inicial da pesquisa e após 8 semanas. As avaliações foram conduzidas pelos mesmos avaliadores treinados. A análise da composição corporal foi realizada no equipamento de absortiometria de raios X de dupla energia (DEXA) que permite estimar a composição corporal no todo e por segmento. As participantes do GT realizaram um programa de exercícios físicos funcionais, 3 dias da semana (não consecutivos), com sessões compostas por 11 estações de exercícios desenvolvidas em formato de circuito. Os exercícios realizados tinham como proposta o desenvolvimento das capacidades força, agilidade, coordenação e propriocepção, e eram seguidos de exercício aeróbio (caminhada). Depois de constatada normalidade dos dados verificada pelo teste Shapiro-Wilk (p<0,05), procedeu-se ao teste t de Student para amostras independentes para verificação de possíveis diferenças em variáveis de composição corporal e antropométricas entre grupos nos dois momentos da intervenção (pré e pós-teste). Todas as análises foram realizadas com o software SPSS, v. 17.0 (SPSS Inc., Chicago, IL, USA) com valor de ...

PURPOSE: To evaluate the effect of 8 weeks of functional training on body composition in postmenopausal women. METHODS: The study was conducted on 38 postmenopausal women, divided into two groups: Training Group (TG) and Control Group (CG). TG women (n=21) performed a program of physical exercise for a period of 8 weeks, 3 times a week on nonconsecutive days, with 90 minutes per session. For the same period, CG women (n=17) did not perform any systematic physical activity. All participants were assessed at baseline and after 8 weeks. The evaluations were performed by the same trained raters. Analysis of body composition was performed using dual-energy X-ray absorptiometry (DEXA), which allows estimation of body composition in the whole body and by segment. TG participants performed a functional exercise program 3 days a week (non-consecutive), with 11 stations consisting of exercises developed in circuit format sessions. The objectives of the exercises were the development of strength, agility, coordination and proprioception, followed by aerobic exercise (walking). After normality of the data was determined by the Shapiro-Wilk test (p<0.05), we applied the Student t-test for independent samples to check for possible differences in anthropometric variables and body composition between groups at both times of intervention (pre and post-test). All analyses were performed using the SPSS software v. 17.0 (SPSS Inc., Chicago, IL, USA) with the level of significance set at 5%. RESULTS: At baseline, no significant difference was observed between groups regarding anthropometric body variables or age composition, indicating homogeneity of the groups. After 8 weeks of training, significant differences were observed between TG and CG regarding fat - CG=0.2±0.7 and TG=-0.4±0.5, total body fat (kg) - CG=0.2±1.3 and TG=-0.7±0.8, and total weight - CG=0.4±1.4 and TG=-0.6±1.1. Percent body fat was reduced in ...